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• Group-V: HFD and nicotine (1.5 mg/kg, b.wt, I.P) (Sinha-Hikim AP, et al ., 2017)+Vitamin-U (100 mg/kg, b.wt) (Sokmen BB, et al ., 2012)+Vitamin E (200 mg/kg, b.wt, oral) (Oliveira CP, et al ., 2003)