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In a cohort with 41,647 participants maternal hypothyroxinemia was associated with preeclampsia (OR 1.32, 95% CI 1.10–1.58) (297), although a more recent individual-participant level metanalysis including 39,826 participants found no association of isolated hypothyroxinemia with either pre-eclampsia or gestational hypertension (250)

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The HCG peptides guide discusses how human chorionic gonadotropin can partially mitigate this shutdown, but prevention is always preferable to rescue