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They include the resistance-nodulation-division (RND) family, the ATP (adenosine triphosphate)-binding cassette (ABC) superfamily, the major facilitator superfamily (MFS), the multidrug and toxic compound extrusion (MATE) family and the small multidrug resistance (SMR) family (Sun et al., 2014)

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Furthermore, the synthesis and modification processes may employ harsh surfactants (e.g., CTAB), which could prove deleterious to human health if not completely removed