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NNMT is an enzyme that influences methylation processes and is involved in the regulation of nicotinamide and S-adenosylmethionine (SAM) pools

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Neurol., 61, 111-124, 2002) leading to excess production of N-methylpyridinium ions in the brain that act as neurotoxins linked to the pathogenesis of neurodegeneration (See e.g., Herraiz T