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A study measuring plasma levels of free heme and hemopexin (a molecule that binds to heme facilitating its degradation) found that the ratio of heme to hemopexin was strongly associated with different malaria complications, including severe anemia, respiratory distress and acute kidney damage, as well as mortality after 6 months ( It is possible that oxidative stress contributes to infected erythrocyte sequestration in the brain microvasculature by inducing increased expression of endothelial adhesion molecules such as ICAM-1 and CD36 ( It has also been proposed that oxidative stress may promote malaria-induced thrombocytopenia, since there was a negative correlation between the number of platelets and levels of lipid peroxidation in malaria patients ( Several clinical trials have been performed to test the efficacy of the antioxidant N-Acetylcysteine (NAC) as an adjunctive treatment for severe malaria

Combine with a balanced diet and regular exercise for optimal brain and energy support.