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Linagliptin, a DPP-4 inhibitor, ameliorates Abeta (1-42) peptides induced neurodegeneration and brain insulin resistance (BIR) via insulin receptor substrate-1 (IRS-1) in rat model of Alzheimer’s disease

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In mammalian cells, DNA is methylated at approximately 70%–80% of CpG cytosine C5 sites, but also at non-CpG sites (He and Ecker, 2015)

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