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An innovative Synbiotic formulation decreases free serum Indoxyl sulfate, small intestine permeability and ameliorates gastrointestinal symptoms in a randomized pilot trial in stage IIIb-IV CKD patients

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Molecular mechanisms similar to those listed above also apply for natural phenolic and polyphenolic substances that have been shown to stabilize native states [169,170] or to remodel and inactivate toxic amyloid oligomers by several mechanisms [171–173] that may differ depending on whether they are glycated or not [174]