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Clinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom - Tanna - 2023 - Clinical Pharmacology & Therapeutics - Wiley Online Library

For gut-related endpoints like ulcer healing, oral may be more directly relevant

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Copper peptides should be avoided by anyone with a known copper allergy, those with active inflammatory skin conditions like a rosacea flare or severe eczema, anyone whose skin barrier is severely compromised, and (until more research is available) those who are pregnant or breastfeeding