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Moreover, in brain of this APPM631L-modified J20 mouse, in contrast to the regular J20 mouse, Aβ42 deposition was not plaquelike but rather punctate in nature, from which we speculate that Met35 of Aβ42 conceivably could be important in oligomer and subsequent plaque formation as well as in oxidative damage associated with this neurotoxic peptide (119)

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As a consequence, this genetically engineered strain not only achieved full resistance against phages but also established a significant restriction on the transfer of genetic material between organisms employing divergent genetic codes