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PMID: 35290266

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Key Points Pathophysiological pain such as inflammatory, neuropathic and cancer pain is characterized by increased pain sensitivity Despite a number of approved analgesics, pain therapy is often unsatisfactory because of low efficacy and adverse effects Pathophysiological pain is associated with a number of different types of epigenetic modulation Future therapeutic interventions in patients who experience pain might target tissue-specific and cell-specific epigenetic mechanisms with histone deacetylase inhibitors, DNA methyltransferase inhibitors, and microRNA mimics or inhibitors Abstract More than 20% of adults worldwide experience different types of chronic pain, which are frequently associated with several comorbidities and a decrease in quality of life