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This group also synthesized and identified a far more potent ISA derivative, Derivative 10 (Figure 2J) ((3αR, 4αR, 6R, 8αR, 9αR)-8α-methyl-3,5-dimethylene-2-oxododecahydronaphtho [2,3-b]furan-6-yl 4,6-dichloronicotinate), which inhibits NLRP3 with an IC 50 of 0.29 μM (Zhao et al., 2024)