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For instance, NR supplementation in preclinical studies has been shown to reduce chemotherapy-induced peripheral neuropathy,¹⁸ inhibit cancer metastasis,³⁵ and, in some cases, enhance tumor-suppressive effects.³⁶ A brief summary of these findings can be found below in the Appendix in Table 1, illustrating that NAD+ metabolism is complex and may be protective under certain conditions

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It is strongly associated with aspirin use in children and adolescents recovering from viral infections (e.g., influenza, varicella)