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Rapidly progressing maculopathy with severe photoreceptor and ganglion cell loss, renal thrombotic microangiopathy, hemolytic uremic syndrome, pulmonary hypertension, and pulmonary thrombotic events have also been described in adult-onset cobalamin C defect (42

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Among such proteins is a large collection of small GTPases, biological switches that upon converting GTP to GDP trigger a variety of signaling cascades