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PDF) FDA Warning Letter Trends: A 15-Year Analysis

ATMs secrete pro-inflammatory cytokines (TNF-α, IL-6, MCP-1) that further impair adipocyte insulin signaling and lipolysis, while hypertrophic adipocytes release free fatty acids (FFAs) and damage-associated molecular patterns (DAMPs) that activate macrophage NLRP3 inflammasomes [75,76]

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& Visioli, F