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These data were confirmed in 2022 by a meta-analysis in which metformin utilisation after HCC curative treatment increased 3-year [OR = 1.50, 95% CI: 1.22–1.83] and 5-year (OR 1.88, 95% CI: 1.47–2.41) overall survival and decreased 1-year (OR = 1.31, 95% CI: 1.08–1.59), 3-year (OR = 1.88, 95% CI: 1.48–2.37), and 5-year (OR = 1.83, 95% CI: 1.40–2.40) recurrence rates [172]

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Endothelial dysfunction also has been shown to cause increased cardiovascular risk in patients with NAFLD (16)