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Figure 2 3 The role and regulatory mechanism of plant-derived bioactive peptides in the regulation of diabetic cognitive impairment 3.1 As a carbohydrate-digesting enzyme inhibitor to regulate diabetic cognitive impairment A key aspect of diabetes management is the inhibition of enzymes involved in carbohydrate digestion, particularly α -glucosidase and α-amylase, which play a key role in blood glucose regulation, and inhibition of these enzymes delays the hydrolysis of dietary starch in the digestive system, lowering blood glucose levels, slowing glucose metabolism, and delaying glucose absorption ( α -amylase activity requires calcium ions to maintain structural integrity and is activated by chloride ions, and similarly, α-glucosidase operates via a Koshland double displacement reaction mechanism ( α -glucosidase inhibitory activity in legumes, cereals and nuts have been studied, and the inhibition effect of different enzymatically hydrolysed protein peptides α-glucosidase has been found to be significantly different
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