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Bioinformatics analysis Most of the data analysis was performed using custom scripts in R (64 bit version 3.6.0) with packages data.table (1.12.2), bit64 (0.9-7), doParallel (1.0.14), stringr (1.4.0), ggplot2 (3.1.1), qplot (3.0.1.1), limma (3.40.0), samr (3.0), magrittr (1.5), scales (1.0.0), XML (3.98-1.19), PerseusR (0.3.4), Biostrings (2.52.0), and MASS (7.3-51.4)

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