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mTOR, Autophagy, and Lipid Homeostasis In addition to supporting fasting glucose homeostasis, autophagy contributes to the hydrolysis of lipid droplets upon nutrient deprivation by the delivery of lipid droplets to lysosomes, and pharmacologic and genetic inhibition of autophagy in the liver leads to the accumulation of lipid droplets and to lower rates of β-oxidation both in vitro and in vivo (Singh et al., 2009a)