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Notably, 1,25(OH)₂D may be a more sensitive predictor of AKI and adverse outcomes in critically ill patients than 25(OH)D is (57)

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These pathways modulate neuronal excitability in key metabolic nuclei including the area postrema, nucleus tractus solitarius, and hypothalamic arcuate nucleus, where amylin signalling is understood to suppress nociceptive and orexigenic inputs