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Interestingly, PTPN22 variants have been associated with several diseases related to the immune system, including rheumatoid arthritis, systemic lupus erythematosus, and Crohn's disease, which characterizes it as a pleiotropic gene for autoimmune diseases.27,28 The IKZF4 gene, associated with vitiligo in European and Chinese individuals, exerts a FOXP3-mediated gene silencing on T regulatory cells (Tregs).29 The FOXP3 gene located on the X chromosome was also a risk factor for vitiligo in several ethnicities

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