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Similarly, DEHP impairs calcium handling by activating transient receptor potential vanilloid 1 (TRPV1) channels and the reverse-mode sodium/calcium exchanger (NCX), with additional involvement of PKC, potassium channels and sarco/endoplasmic reticulum calcium ATPase (SERCA), ultimately leading to negative chronotropic and inotropic effects and reduced cardiomyocyte contractility (Rodrigues et al., 2020)

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