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Granulocyte-macrophage colony-stimulating factor stimulates JAK2 signaling pathway and rapidly activates p93fes, STAT1 p91, and STAT3 p92 in polymorphonuclear leukocytes

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So if you are 100 lbs overweight you should lose between 70-80 lbs, for a 200 lbs overweight patient, the estimated weight loss is 140-160 lbs