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In the 52-week STEP-HFpEF study, besides significant weight reduction in obese patients with heart failure with preserved ejection fraction treated with once-weekly subcutaneous 2.4 mg semaglutide, a decrease in heart failure symptoms (fatigue, dyspnea, and edema) and improvement in physical performance were observed [82]

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NAD+ is the most cited example: it is a comparatively high-volume, sometimes uncomfortable injection that some research protocols describe delivering IM (or slow SubQ) rather than as a fast SubQ bolus