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The frequencies of the PNPLA3 GG allele and the FADS2 TT allele in the advanced fibrosis group were higher (64% and 57%, respectively) than in the non-advanced fibrosis group (50% and 38%), whereas the frequencies of the FADS1 TT allele were almost similar in both groups (21% and 23%)

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Understanding the mechanisms of methamphetamine toxicity is essential to develop treatment strategies to reverse or attenuate the progress of methamphetamine-associated organ damage