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The S2 subsite is also sufficiently deep to accommodate a larger side chain and is lined by the side chains of Lys208, Arg220 and Thr222 from the N-terminal barrel and Phe673 from the C-terminal barrel

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Low zinc levels are negatively correlated with the expression of nod-like receptor nucleotide-binding domain and leucine-rich repeat pyrin-3 domain (NLRP3), IL-1β, and IL-18 (155) and are currently considered a risk factor for the development of chronic kidney disease (CKD) or the progression of kidney injury (156–158)