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163−165 AA is the main substrate of both isoforms, but LA is a known competitive substrate and inhibitor of prostaglandin formation by COX-1 and COX-2

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No significant changes were observed in resting tremor scores for placebo (0.92 [−0.12 to 1.96]) or niacin (0.1 [−0.56 to 0.76]) groups

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