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In the early 21st century, when no disease-modifying treatments for AD were available, diagnostic biomarkers with mechanistic specificity, such as CSF Aβ 1–42 /tau ratios or amyloid PET imaging, began to serve a dual role as selection biomarkers in clinical trials

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doi: 10.1016/j.celrep.2018.12.002 114 AbeYSakata-YanagimotoMFujisawaMMiyoshiHSueharaYHattoriKet al