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4 Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, Merseyside, UK Correspondence: Duolao Wang, Email [email protected] Abstract: COPD (chronic obstructive pulmonary disease) is a major public health concern associated with significant morbidity and mortality worldwide

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16 mTORC2, as a growth factor integrating variety of signaling pathway, phosphorylates the 26th serine of SLC7A11 to reduce its activity, thereby inhibiting cystine intake and glutathione metabolism

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