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The G 2 /M arrest in Nrf2 − / − alveolar epithelial cells has been reported to be associated with reduced phosphorylation of retinoblastoma protein (at Ser-807/Ser-811) and inactivation and mislocalization of cyclin B1 and cyclin-dependent kinase (CDK) 1, both of which are involved in the mitosis-promoting factor complex

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