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As a major metabolic byproduct, ammonia plays multifaceted roles in the TME, influencing tumor progression, immune evasion, and therapeutic responses (89, 90)

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A total of 70 male Sprague–Dawley rats were systematically allocated into seven distinct groups, inclusive of control and three dosage categories of Rhodiola extract (1.5, 3, and 6 g/kg)

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