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Moreover, experimental findings suggest that neutrophil ROS and proteases contribute to superficial erosion in vulnerable plaques (Hosokawa et al., 2011)

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Regarding substrate oxidation, we did observe improvement in metabolic flexibility upon carnitine supplementation, consistent with our previous finding, 9 but this effect was only observed in the low insulin phase of the clamp, although RER also tended to be increased upon carnitine supplementation during high insulin infusion