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Most normal FXN alleles have 8–9 repeats, a few up to 30–35, while expanded alleles contain from 70 to over 1700 repeats that interfere with FXN transcription by heterochromatin silencing (2–4)

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Furthermore, the development of modern technologies such as nanoparticles or targeted drug carriers can increase the bioavailability and efficacy of antioxidants, making these therapies even more promising