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[DOI] [PubMed] [Google Scholar] 71.Pappenheimer JR, Reiss KZ

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In the hindlimb unloading-induced atrophy model, reduced mitochondrial respiration, calcium retention capacity, and increased oxidative stress are closely associated with muscle function decline, suggesting that maintaining mitochondrial function is critical for muscle recovery ( 3.8 Caspase-3 Under both normal and low-temperature conditions, apoptotic factors such as caspase-3 are activated during hindlimb unloading-induced atrophy, accompanied by DNA fragmentation and lipid peroxidation

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