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Nevertheless, other authors point to Systems L (facilitative-transporter) and N (active transport) as having a predominant role in Gln homeostasis, due to abundant expression and endothelium membrane localization of LAT1 and SNAT3 (SCL38A3) ( + was thought to be restricted to the abluminal membrane, but the presence of some members of this system on both sides has been detected in murine and rat models ( Glutamate Transport: Systems X G – and X C – Studies using isolated membranes from the BBB revealed that facilitative carriers for glutamate (Glu) only existed on the luminal side, while sodium-dependent active co-transporters were confined to the abluminal membrane ( + -independent transporter was a path for Glu entry into the brain
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