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In addition, when the electron transport chain is impaired, there is an increase in free radical generation, both reactive oxygen species (ROS) and reactive nitrogen species (RNS).[85] Aluminum is known to concentrate in the mitochondria of neurons, microglia, and astrocytes and reduces energy production.[54,76] Excitotoxicity is significantly enhanced under such conditions, making a direct biochemical link to mitochondrial impairment in neurodegenerative diseases.[2,8,68] Mitochondria are also responsible for calcium regulation within the cell.[17,20] Dysfunction of this control system can lead to calcium accumulation within the cell and subsequent apoptosis

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