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HPA axis dysregulation by ROS in turn causes a proinflammatory response with increased circulating levels of PIC.56 Unrestricted ROS activity is also responsible for increased blood-brain barrier permeability through launching of matrix metalloproteinases and subsequent degradation of tight junctions, unrepressed neuroinflammation, and enhanced apoptosis of neurons.57 3

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These groups include children, the elderly, women, people with certain previous health conditions, and people exposed to manganese in their environment or work