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Profile B β€” Normal CYP1B1 Β· Val/Val COMT Β· C/C MTHFR Β· Arg/Arg SULT1A1 Β· GSTM1 present Β· Low ESR1 sensitivity: Phase 1 generates a favorable 2-OHE2:4-OHE2 ratio

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For example, Ξ²-naphtoflavone, a planar aromatic xenobiotic, modulates Ξ³-glutamate-cysteine ligase in the liver cell line HepG2 through TRE/AP1 and ARE [95]

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