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Profile B โ€” Normal CYP1B1 ยท Val/Val COMT ยท C/C MTHFR ยท Arg/Arg SULT1A1 ยท GSTM1 present ยท Low ESR1 sensitivity: Phase 1 generates a favorable 2-OHE2:4-OHE2 ratio

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For example, ฮฒ-naphtoflavone, a planar aromatic xenobiotic, modulates ฮณ-glutamate-cysteine ligase in the liver cell line HepG2 through TRE/AP1 and ARE [95]

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