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Finally, we highlight the challenges that face the therapeutic targeting of the MAT2A/PRMT5 axis, the need for additional predictive biomarkers other than MTAP status, and how these biomarkers could predict rational combination therapies

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However, these florescent probes are susceptible to various drawbacks such as photo-bleaching and molecular leaching from the host, which may result in serious experimental artifacts 6,7,8,9