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Vitamin B12 plays an essential role as a cofactor in the conversion of homocysteine to methionine and 5-methyl tetrahydrofolate to tetrahydrofolate

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Vitamin Supplementation In patients with creatinine clearances between 45 mL/min and 79 mL/min, modify administration of ibuprofen as follows [see Warnings and Precautions (5.6), Drug Interactions (7) and Clinical Pharmacology (12.3)]: Obtain complete blood count on Days 1, 8, and 15 of each cycle

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