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TNF-alpha, interleukin-6 (IL-6), interleukin-1-beta (IL-1B), and interferon-gamma (IFN-gamma) drive persistent inflammation that damages tissue over time

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A 2020 review in Current Pharmaceutical Design examined its described role in maintaining epithelial integrity and intestinal permeability in the context of NSAID exposure, alcohol, and bile acids, in preclinical models [8]