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Foresta et al suggested that hypotestosteronemia was related to the reduction of circulating EPCs in young hypogonadotropic hypogonadal men 52 , whereas the reduction of EPCs could be reversed by the testosterone replacement through a direct stimulatory effect on the bone marrow 53 , and the androgen receptor/VEGF/cyclin A-mediated mechanism may be involved in this process 54

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J.De ReuH.SmitsE.GoossensH.et al (2018)