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Its core pathophysiological characteristics are intricately intertwined with abnormal iron and lipid metabolism, oxidative stress, mitochondrial dysfunction, and neuroinflammation, driving the progressive degeneration of dopaminergic neurons in the substantia nigra (SN) ( Figure 2 )

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The downstream cascades of HGF/c-Met include JAK/STAT3, PI3K/Akt/NF-κB, and Ras/Raf pathways, affecting cell proliferation, growth, and survival