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Introduction It is well-known that the brain is susceptible to oxidative stress, for reasons including high metabolic needs, oxidative stress associated with the production and storage of neurotransmitters, and sparse antioxidant defenses (Cobley et al., 2018)

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soluble hyaluronidases include membrane anchored hyaluronidases in which one or more regions associated with anchoring of the hyaluronidase to the membrane has been removed or modified, where the soluble form retains hyaluronidase activity