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These conditions may include metabolic syndromes, tumors, poisoning, chronic exposure to heavy metals, chronic inflammation, and neurological diseases

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Furthermore, the glutathione redox state declines in the liver, kidney, heart, testis, eye and brain of mice during aging [6], while old long-living dwarf mice display significantly higher activities of GCL and GST in the kidney when compared to age-matched wild-type mice [50]