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Epigenetic changes Recent epigenome-wide association studies identified changes in DNA methylation levels distributed across the genome and within many genes of interest, including the GABA transporter SLC6A12 , the GABA receptor GABBR1 , the calcium voltage-gated channel subunit CACNA1C , and the mitotic arrest deficient 1-like 1 (MAD1L1) [258, 259]