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In particular, results from both human and murine studies demonstrate increased production of the enzymes neutrophil elastase and myeloperoxidase (Figure 3), which is worrisome as elevations in these have been associated with the development of COPD, coronary artery disease, atherosclerosis, non-alcoholic fatty liver disease (NAFLD), type II diabetes, and autoimmune disorders such as lupus (56)

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Additionally, the high cost of MSC therapy, often reaching tens of thousands of dollars, further limits its widespread use