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It would be interesting to investigate if increased γ-glutamylcysteine could explain the drug resistance observed in tumours associated with γ-glutamyltransferase overexpression 26

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Overall, these results suggest that 3D-spheroids augmented their high-energy substrate levels by upregulating not only the synthesis, but also the phosphorylation of both purine and pyrimidine nucleotides, including ATP (Fig