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Common ulcerative colitis treatment approaches include: Medications: Aminosalicylates, Corticosteroids and Immunosuppressants Biologic Therapies: Anti-tumour necrosis factor (TNF) agents (e.g., infliximab, adalimumab), anti-integrin agents (e.g., vedolizumab), or anti-interleukin 12/23 agents (e.g., ustekinumab) are reserved for moderate to severe ulcerative colitis that doesn't respond to other treatments JAK Inhibitors: Janus kinase (JAK) inhibitors (e.g., tofacitinib) may be prescribed for moderate to severe ulcerative colitis therapy in adults Rectal Therapies Rectal 5-aminosalicylate: This can be used to treat inflammation localised in the rectum or lower part of the colon