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Oxidative stress can damage insulin sensitivity and lead to insulin resistance and cognitive dysfunction of diabetes by downregulating the proteins involved in normal IST, such as Insulin-degrading enzyme (IDE), Biliverdin reductase-A (BVR-A), Akt, IRS, IRS-1 and GSK-3 (83, Insulin resistance can occur in both obesity and diabetes and is manifested in peripheral and central insulin resistance (106)