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DPYD genotyping led to changes in clinical conduct by permitting fluoropyrimidine treatment modifications (dose modifications or avoiding fluoropyrimidines) Given the imprecision in study results, it is uncertain whether genotype-guided dose reduction in heterozygous DPYD carriers led to a risk of severe toxicity and toxicity-related hospitalization that was comparable to that of wild-type patients on a standard dose (GRADE: Very low) One study compared DPYD carriers treated with a reduced fluoropyrimidine dose and DPYD carriers treated with a standard dose
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